Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20350866 | 0.88 | KDM4E (0.38) | KDM4ETSHRALDH1A1MAPTHTT | |
| SCHEMBL20350882 | 0.87 | KDM4E (0.38) | KDM4ETSHRALDH1A1MAPT | |
| SCHEMBL20350844 | 0.84 | KDM4E (0.39) | KDM4ETSHRALDH1A1MAPTHTT | |
| SCHEMBL20340117 | 0.80 | KDM4E (0.57) | KDM4ETSHRALDH1A1MAPTHTT | |
| SCHEMBL20350899 | 0.77 | ALDH1A1 (0.39) | KDM4ETSHRALDH1A1MAPTHPGD | |
| SCHEMBL20350847 | 0.77 | KDM4E (0.66) | KDM4ETSHRALDH1A1MAPTHTT | |
| SCHEMBL20340026 | 0.76 | ALDH1A1 (0.40) | KDM4ETSHRALDH1A1MAPTHPGD | |
| SCHEMBL20350843 | 0.72 | KDM4E (0.40) | KDM4ETSHRALDH1A1MAPTHTT | |
| SCHEMBL20340131 | 0.70 | CYP1A2 (0.49) | KDM4ETSHRALDH1A1MAPTHTT | |
| SCHEMBL20340035 | 0.69 | KDM4E (0.61) | KDM4ETSHRALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018125983-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | MITOBRIDGE, INC. (US) | 2018-07-05 | — | — | WO | disclosed |