Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.42 |
| ▸ | LCK | P06239 | 4/20 | 0.42 |
| ▸ | SRC | P12931 | 4/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | YES1 | P07947 | 2/20 | 0.42 |
| ▸ | LYN | P07948 | 2/20 | 0.42 |
| ▸ | HCK | P08631 | 2/20 | 0.42 |
| ▸ | FGR | P09769 | 2/20 | 0.42 |
| ▸ | TXK | P42681 | 2/20 | 0.42 |
| ▸ | BLK | P51451 | 2/20 | 0.42 |
| ▸ | BMX | P51813 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FRK | P42685 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20351579 | 0.89 | BTK (0.54) | BTKKCNH2LCKSRCFYN | |
| SCHEMBL20351562 | 0.86 | MET (0.42) | BTKKCNH2LCKSRCFYN | |
| SCHEMBL20351711 | 0.81 | SRC (0.52) | BTKLCKSRCFYNLYN | |
| SCHEMBL22418481 | 0.79 | BTK (0.55) | BTKKCNH2LCKSRCFYN | |
| SCHEMBL20351656 | 0.79 | SRC (0.44) | LCKSRC | |
| SCHEMBL20351551 | 0.79 | ADK (0.39) | BTKKCNH2LCKSRCABL1 | |
| SCHEMBL20351435 | 0.79 | SRC (0.46) | LCKSRCABL1 | |
| SCHEMBL20351559 | 0.78 | ADK (0.40) | BTKKCNH2LCKSRCABL1 | |
| SCHEMBL20351775 | 0.78 | SRC (0.52) | BTKLCKSRCFYNLYN | |
| SCHEMBL20351629 | 0.77 | SRC (0.42) | LCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018121228-A1 | COMPOUND HAVING AXL INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海药物研究所 | 2018-07-05 | — | — | WO | disclosed |