Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2163506 | 0.84 | GBA1 (0.45) | CYP3A4HSD17B10LMNAGBA1ALDH1A1 | |
| SCHEMBL2015058 | 0.83 | GBA1 (0.45) | CYP3A4HSD17B10LMNAGBA1ALDH1A1 | |
| SCHEMBL2164804 | 0.81 | GBA1 (0.43) | CYP3A4HSD17B10LMNAGBA1ALDH1A1 | |
| SCHEMBL2017545 | 0.81 | GBA1 (0.43) | CYP3A4HSD17B10LMNAGBA1ALDH1A1 | |
| SCHEMBL2016485 | 0.73 | PIK3CD (0.41) | CYP3A4HSD17B10LMNAGBA1ALDH1A1 | |
| SCHEMBL2053755 | 0.73 | L3MBTL1 (0.51) | HSD17B10LMNAALDH1A1HPGDGAA | |
| SCHEMBL2015986 | 0.72 | L3MBTL1 (0.48) | HSD17B10LMNAALDH1A1HPGDGAA | |
| SCHEMBL2016487 | 0.72 | GBA1 (0.35) | CYP3A4HSD17B10LMNAGBA1ALDH1A1 | |
| SCHEMBL2163899 | 0.71 | MEN1 (0.54) | LMNAALDH1A1SMN1; SMN2MAPK1MEN1 | |
| SCHEMBL2014280 | 0.71 | MEN1 (0.52) | CYP3A4LMNAALDH1A1CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |