SCHEMBL20353147

SCHEMBL20353147

CC(=O)Oc1ccc2c(c1)Oc1cc(OC(C)=O)ccc1C21OC(=O)c2cc(C)ccc21

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.78
LMNA P02545 4/20 0.78
ALDH1A1 P00352 3/20 0.78
MEN1 O00255 2/20 0.78
HTT P42858 2/20 0.78
KMT2A Q03164 2/20 0.78
USP2 O75604 1/20 0.78
GSTP1 P09211 1/20 0.72
CYP3A4 P08684 1/20 0.53
FTO Q9C0B1 8/20 0.50
HPGD P15428 1/20 0.47
CYP2C19 P33261 1/20 0.47
RECQL P46063 1/20 0.47
BLM P54132 1/20 0.47
SMAD3 P84022 1/20 0.47
PRMT1 Q99873 1/20 0.47
ACE2 Q9BYF1 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
MAOB P27338 2/20 0.42
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14769054 0.92 MAPT (0.89) MAPTLMNAALDH1A1MEN1HTT
SCHEMBL13620842 0.92 MAPT (0.77) MAPTLMNAALDH1A1MEN1HTT
SCHEMBL12576106 0.91 MAPT (0.69) MAPTLMNAALDH1A1MEN1HTT
SCHEMBL12576109 0.91 MEN1 (0.69) MAPTLMNAALDH1A1MEN1HTT
SCHEMBL16994104 0.90 LMNA (0.68) MAPTLMNAALDH1A1MEN1HTT
Fluorescein Diacetate SCHEMBL29453229 0.88 MAPT (1.00) MAPTLMNAALDH1A1MEN1HTT
Fluorescein Diacetate SCHEMBL1028369 0.88 MAPT (1.00) MAPTLMNAALDH1A1MEN1HTT
Fluorescein Diacetate SCHEMBL29353816 0.88 MAPT (1.00) MAPTLMNAALDH1A1MEN1HTT
Fluorescein Diacetate SCHEMBL31658971 0.88 MAPT (1.00) MAPTLMNAALDH1A1MEN1HTT
SCHEMBL16330615 0.87 MAPT (0.60) MAPTLMNAALDH1A1MEN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3562823-B1 FUNCTIONALIZED NANOLUC INHIBITORS PROMEGA CORP (US) 2023-02-08 EP disclosed
WO-2018125992-A1 FUNCTIONALIZED NANOLUC INHIBITORS PROMEGA CORPORATION (US) 2018-07-05 WO disclosed