Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18389808 | 0.86 | CHRM1 (0.48) | MMP1MMP2MMP8CHRM1PIK3CD | |
| SCHEMBL18713203 | 0.80 | HSD17B10 (0.45) | MMP1MMP2MMP8CHRM1ALDH1A1 | |
| SCHEMBL20154460 | 0.77 | ROCK2 (0.38) | MMP1MMP2MMP8CHRM1ALDH1A1 | |
| SCHEMBL18704895 | 0.76 | MMP1 (0.38) | MMP1MMP2MMP8CHRM1PIK3CD | |
| SCHEMBL1622973 | 0.75 | MMP1 (0.40) | MMP1MMP2MMP8POLB | |
| SCHEMBL1622976 | 0.75 | MMP1 (0.40) | MMP1MMP2MMP8POLB | |
| SCHEMBL20154581 | 0.73 | POLB (0.56) | ALDH1A1POLBNPSR1L3MBTL1 | |
| SCHEMBL22875187 | 0.72 | MEN1 (0.40) | MMP1MMP2MMP8ALDH1A1POLB | |
| SCHEMBL22875185 | 0.72 | MEN1 (0.40) | MMP1MMP2MMP8ALDH1A1POLB | |
| SCHEMBL22874728 | 0.72 | MEN1 (0.40) | MMP1MMP2MMP8ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186791-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186791-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | MMP1 4508/4885MMP2 4141/4885MMP8 4396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.