Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.53 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.47 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1199259 | 0.89 | NAMPT (0.57) | NAMPTKMT2AKDM4EPKMGPR119 | |
| SCHEMBL4181896 | 0.88 | HDAC4 (0.57) | NAMPTKMT2AKDM4EPKMGPR119 | |
| SCHEMBL1198897 | 0.86 | NAMPT (0.60) | NAMPTKMT2AKDM4EPKMGPR119 | |
| SCHEMBL4088593 | 0.85 | NAMPT (0.54) | NAMPTKMT2AKDM4EPKMGPR119 | |
| SCHEMBL226854 | 0.85 | NAMPT (0.59) | NAMPTKMT2AKDM4EPKMGPR119 | |
| SCHEMBL22564659 | 0.85 | GPR119 (0.67) | NAMPTKMT2AKDM4EPKMGPR119 | |
| SCHEMBL557627 | 0.84 | KDM4E (0.73) | NAMPTKMT2AKDM4EPKMGPR119 | |
| SCHEMBL229512 | 0.84 | NAMPT (0.58) | NAMPTKMT2AKDM4EGPR119DDB1 | |
| SCHEMBL6132207 | 0.84 | GPR119 (0.67) | NAMPTKMT2AKDM4EGPR119DDB1 | |
| SCHEMBL6917548 | 0.84 | NAMPT (0.67) | NAMPTKDM4EGPR119DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186787-A1 | PHARMACEUTICAL COMPOUND | MERCK SHARP & DOHME CORP. (US) | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186787-A1 | PHARMACEUTICAL COMPOUND | TDO2, IDO2, IDO1 | NAMPT 230/4885KMT2A 1222/4885KDM4E 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.