Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.67 |
| ▸ | NPC1 | O15118 | 8/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GPR68 | Q15743 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14582063 | 0.86 | RAB9A (0.56) | RAB9ANPC1JAK2SMN1; SMN2HTT | |
| SCHEMBL10878944 | 0.86 | ADORA3 (0.63) | RAB9ANPC1JAK2HTTMAPK1 | |
| SCHEMBL796156 | 0.85 | BCL6 (0.61) | RAB9ANPC1SMN1; SMN2HTTADORA2A | |
| SCHEMBL2494840 | 0.80 | RAB9A (1.00) | RAB9ANPC1JAK2SMN1; SMN2HTT | |
| SCHEMBL24359535 | 0.80 | HSP90AB1 (0.44) | RAB9ANPC1JAK2SMN1; SMN2HTT | |
| SCHEMBL10910614 | 0.80 | CA12 (0.68) | RAB9ANPC1JAK2SMN1; SMN2HTT | |
| SCHEMBL12253181 | 0.80 | NPC1 (0.61) | RAB9ANPC1JAK2SMN1; SMN2HTT | |
| SCHEMBL4572276 | 0.79 | CA12 (0.53) | RAB9ANPC1JAK2SMN1; SMN2LMNA | |
| SCHEMBL16199978 | 0.79 | CA9 (0.59) | RAB9ANPC1JAK2HTTCA12 | |
| SCHEMBL14972695 | 0.79 | SYK (0.51) | RAB9ANPC1JAK2SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018122775-A1 | HETEROARYL COMPOUNDS AND THEIR USE | MINORYX THERAPEUTICS S.L. (ES) | 2018-07-05 | — | — | WO | disclosed |