Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12912264 | 0.79 | KDM4E (0.56) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL6631672 | 0.78 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL12891157 | 0.75 | ALDH1A1 (0.40) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL8646848 | 0.74 | KDM4E (0.38) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL14030430 | 0.68 | MEN1 (0.47) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL13248529 | 0.68 | ALDH1A1 (0.40) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL13248528 | 0.68 | ALDH1A1 (0.40) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL903236 | 0.68 | ALDH1A1 (0.60) | ALDH1A1KDM4ESMN1; SMN2SCN5AHTT | |
| SCHEMBL2267586 | 0.64 | ALDH1A1 (0.75) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL12911394 | 0.63 | ALDH1A1 (0.64) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10316044-B2 | Chiral diaryl macrocycles as modulators of protein kinases | TP THERAPEUTICS, INC. (US) | 2019-06-11 | — | — | US | disclosed |
| US-20180186813-A1 | CHIRAL DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | Turning Point Therapeutics, Inc. | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186813-A1 | CHIRAL DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | MAP3K20, LCK, DAPK2 | ALDH1A1 4607/4885KDM4E 1625/4885SMN1; SMN2 2362/4885 |
| US-10316044-B2 | Chiral diaryl macrocycles as modulators of protein kinases | LCK, MAP3K20, MAP3K1 | ALDH1A1 4146/4885KDM4E 2118/4885SMN1; SMN2 1776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.