Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 17/20 | 0.51 |
| ▸ | BRD4 | O60885 | 15/20 | 0.51 |
| ▸ | BRD2 | P25440 | 1/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16905795 | 0.82 | CREBBP (0.51) | CREBBPBRD4BRD2BRD3CYP3A4 | |
| SCHEMBL20357688 | 0.80 | BRD4 (0.49) | CREBBPBRD4BRD2BRD3ALDH1A1 | |
| SCHEMBL20357612 | 0.78 | BRD4 (0.46) | CREBBPBRD4BRD2BRD3CYP1A2 | |
| SCHEMBL20357624 | 0.78 | BRD4 (0.46) | CREBBPBRD4BRD2BRD3ALDH1A1 | |
| SCHEMBL20357588 | 0.78 | BRD4 (0.44) | CREBBPBRD4BRD2BRD3CYP1A2 | |
| SCHEMBL20357605 | 0.77 | BRD4 (0.42) | BRD4BRD2BRD3CYP1A2CYP3A4 | |
| SCHEMBL20357585 | 0.76 | BRD4 (0.47) | CREBBPBRD4BRD2BRD3ALDH1A1 | |
| SCHEMBL20357601 | 0.75 | BRD4 (0.54) | CREBBPBRD4BRD2BRD3CYP1A2 | |
| SCHEMBL20357625 | 0.74 | BRD4 (0.47) | CREBBPBRD4BRD2BRD3ALDH1A1 | |
| SCHEMBL20357646 | 0.74 | BRD4 (0.41) | BRD4BRD2BRD3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | claimed |