⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874014 | 0.69 | EGFR (0.58) | — | |
| SCHEMBL127479 | 0.67 | EGFR (0.50) | — | |
| SCHEMBL6119198 | 0.65 | EGFR (0.50) | — | |
| SCHEMBL29865299 | 0.65 | EGFR (0.50) | — | |
| SCHEMBL28003243 | 0.64 | EGFR (0.48) | — | |
| SCHEMBL137377 | 0.63 | EGFR (0.60) | — | |
| Quinazoline SCHEMBL29490398 | 0.63 | EGFR (1.00) | — | |
| SCHEMBL29409337 | 0.63 | EGFR (0.60) | — | |
| Quinazoline SCHEMBL29356169 | 0.63 | EGFR (1.00) | — | |
| Quinazoline SCHEMBL5920 | 0.63 | EGFR (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975910-B2 | Hetero-fused cyclic compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-05-22 | — | — | US | claimed |
| US-20160168176-A1 | HETERO-FUSED CYCLIC COMPOUND | Eisai R&D Management Co., Lt.d (JP) | 2016-06-16 | — | — | US | claimed |
| EP-3026054-A1 | HETERO-CONDENSED RING COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2016-06-01 | — | — | EP | claimed |
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3498701-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2023-02-22 | — | — | EP | disclosed |
| US-11185531-B2 | Arginine methyltransferase inhibitors and uses thereof | Epizyme, Inc. (US) | 2021-11-30 | — | — | US | disclosed |
| EP-2970132-B1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2020-09-23 | — | — | EP | disclosed |
| US-20200289469-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. | 2020-09-17 | — | — | US | disclosed |
| US-10632103-B2 | Arginine methyltransferase inhibitors and uses thereof | Epizyme, Inc. (US) | 2020-04-28 | — | — | US | disclosed |
| US-20190343826-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. | 2019-11-14 | — | — | US | disclosed |
| EP-2935247-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2019-08-28 | — | — | EP | disclosed |
| US-7855194-B2 | Pyrimidine, quinazoline, pteridine and triazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-20070225271-A1 | Pyrimidine, quinazoline, pteridine and triazine derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-09-27 | — | — | US | disclosed |
| US-20070027156-A1 | Crf antagonists and heterobicyclic compounds | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-02-01 | — | — | US | disclosed |
| US-20070027156-A1 | Crf antagonists and heterobicyclic compounds | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-02-01 | — | — | US | disclosed |
| US-5486516-A | FUNGICIDES, INSECTICIDES, MITICIDES | DOWELANCO (US) | 1996-01-23 | — | — | US | disclosed |
| US-5137879-A | Fungicide, miticide and insecticide | DOWELANCO (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0459611-A2 | Furopyrimidine derivatives | DOWELANCO (US) | 1991-12-04 | — | — | EP | disclosed |
| EP-0244175-A2 | Furo (3,4-d) pyrimidine-2, 4-dione derivatives and intermediates thereof | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-11-04 | — | — | EP | disclosed |
| US-4703120-A | VASODILATORS, HYPOTENSIVE AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-10-27 | — | — | US | disclosed |