SCHEMBL20360347

SCHEMBL20360347

Clc1nc(Cl)c(Cl)c(Cl)c1Cl.FC(F)(F)c1cc(Cl)c(Cl)nc1Cl

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 1/20 0.33
NOTUM Q6P988 4/20 0.33
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
ADRB2 P07550 1/20 0.32
XPO1 O14980 1/20 0.32
KMO O15229 1/20 0.31
CASP3 P42574 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL675996 0.92 PIK3CD (0.37) PIK3CDNOTUMCYP11B1CYP11B2ADRB2
SCHEMBL29687228 0.92 PIK3CD (0.37) PIK3CDNOTUMCYP11B1CYP11B2ADRB2
SCHEMBL10853416 0.80 PIK3CD (0.40) PIK3CDNOTUMCYP11B1CYP11B2ADRB2
SCHEMBL10746403 0.77 XPO1 (0.31) NOTUMXPO1
SCHEMBL20350717 0.77
SCHEMBL28454953 0.75 NOTUM (0.35) PIK3CDNOTUMCYP11B1CYP11B2CASP3
SCHEMBL21670482 0.75 NOTUM (0.35) PIK3CDNOTUMCYP11B1CYP11B2ADRB2
SCHEMBL30285322 0.75 NOTUM (0.35) PIK3CDNOTUMCYP11B1CYP11B2ADRB2
SCHEMBL7784302 0.73 PIK3CD (0.41) PIK3CDNOTUMADRB2XPO1CASP3
SCHEMBL31717937 0.73 PIK3CD (0.41) PIK3CDNOTUMADRB2XPO1CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180194728-A1 METHOD FOR PREPARING PENTACHLOROPYRIDINE BY UTIILIZING DCTF RECTIFYING SHORT STEAMING RESIDUES YANCHENG INSTITUTE OF TECHNOLOGY 2018-07-12 US disclosed