Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.52 |
| ▸ | KIT | P10721 | 3/20 | 0.52 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30552182 | 0.85 | EPHB3 (0.63) | EPHB3NPC1RAB9AALDH1A1GAA | |
| SCHEMBL9278491 | 0.84 | EPHB3 (0.59) | EPHB3NPC1RAB9AALDH1A1GAA | |
| SCHEMBL9913664 | 0.84 | EPHB3 (0.62) | EPHB3NPC1RAB9AALDH1A1GAA | |
| SCHEMBL21387402 | 0.83 | EPHB3 (0.58) | EPHB3NPC1RAB9AALDH1A1GAA | |
| SCHEMBL29843826 | 0.82 | EPHB3 (0.56) | EPHB3NPC1RAB9AALDH1A1GAA | |
| SCHEMBL2017759 | 0.81 | NPC1 (0.59) | EPHB3NPC1RAB9AADORA2A | |
| SCHEMBL16797995 | 0.81 | DDR2 (0.69) | EPHB3NPC1RAB9AGAADDR2 | |
| SCHEMBL19362092 | 0.81 | EPHB3 (0.55) | EPHB3NPC1RAB9AALDH1A1GAA | |
| SCHEMBL20434869 | 0.81 | NPC1 (0.55) | EPHB3NPC1RAB9AALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL29440777 | 0.80 | NPC1 (0.57) | EPHB3NPC1RAB9AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10196385-B2 | Tetrahydropyranyl benzamide derivatives | ELI LILLY AND COMPANY (US) | 2019-02-05 | — | — | US | disclosed |
| US-10196385-B2 | Tetrahydropyranyl benzamide derivatives | ELI LILLY AND COMPANY (US) | 2019-02-05 | — | — | US | disclosed |
| US-20180194755-A1 | Tetrahydropyranyl Benzamide Derivatives | ELI LILLY AND COMPANY | 2018-07-12 | — | — | US | disclosed |
| US-20180194755-A1 | Tetrahydropyranyl Benzamide Derivatives | ELI LILLY AND COMPANY | 2018-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10196385-B2 | Tetrahydropyranyl benzamide derivatives | INSR, GPR119, GLP1R | EPHB3 2963/4885NPC1 1216/4885RAB9A 1548/4885 |
| US-20180194755-A1 | Tetrahydropyranyl Benzamide Derivatives | INSR, GPR119, GLP1R | EPHB3 2809/4885NPC1 744/4885RAB9A 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.