Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL138865 | 0.84 | — | — | |
| Ammonia Solution, Strong SCHEMBL28052971 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL5558203 | 0.82 | — | — | |
| Glycinebetaine SCHEMBL28177181 | 0.76 | TSHR (0.40) | TSHRALDH1A1LMNAAPEX1MEN1 | |
| Monoethanolamine SCHEMBL28273650 | 0.73 | — | — | |
| Monoethanolamine SCHEMBL21465320 | 0.71 | TSHR (0.50) | TSHRALDH1A1 | |
| Monoethanolamine SCHEMBL5985807 | 0.69 | — | — | |
| Monoethanolamine SCHEMBL28934046 | 0.67 | ALDH1A1 (0.44) | TSHRALDH1A1 | |
| Acetone SCHEMBL10591911 | 0.67 | ALDH1A1 (0.61) | TSHRALDH1A1LMNAKMT2A | |
| Tetramethylammonium Ion SCHEMBL28132458 | 0.67 | ALDH1A1 (0.61) | TSHRALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3565530-A1 | TREATMENT OF PANCREATIC CANCER | Syncore Biotechnology Co., Ltd. (TW) | 2019-11-13 | — | — | EP | claimed |
| WO-2018127082-A1 | TREATMENT OF PANCREATIC CANCER | SYNCORE BIOTECHNOLOGY CO., LTD. (CN) | 2018-07-12 | — | — | WO | claimed |
| EP-3565530-A1 | TREATMENT OF PANCREATIC CANCER | Syncore Biotechnology Co., Ltd. (TW) | 2019-11-13 | — | — | EP | disclosed |
| WO-2018127082-A1 | TREATMENT OF PANCREATIC CANCER | SYNCORE BIOTECHNOLOGY CO., LTD. (CN) | 2018-07-12 | — | — | WO | disclosed |