Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 12/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1960494 | 0.77 | GCK (0.63) | GCK | |
| SCHEMBL2039421 | 0.75 | GCK (0.39) | GCK | |
| SCHEMBL26686565 | 0.73 | GCK (0.43) | GCKDRD2DRD4DRD3 | |
| SCHEMBL2044900 | 0.72 | GCK (0.37) | GCK | |
| SCHEMBL2049518 | 0.71 | MEN1 (0.42) | GCKDRD2DRD4DRD3 | |
| SCHEMBL2038418 | 0.70 | KMT2A (0.38) | GCK | |
| SCHEMBL2054221 | 0.69 | GCK (0.41) | GCKDRD2DRD4DRD3 | |
| SCHEMBL1959200 | 0.69 | GCK (0.51) | GCK | |
| SCHEMBL1962013 | 0.67 | GCK (0.75) | GCK | |
| SCHEMBL1960893 | 0.67 | GCK (0.63) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | claimed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | claimed |