Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 8/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1960463 | 0.76 | GCK (0.69) | GCKRIPK1ALDH1A1NPSR1GAA | |
| SCHEMBL26686565 | 0.73 | GCK (0.43) | GCKDRD2DRD4DRD3 | |
| SCHEMBL2049518 | 0.73 | MEN1 (0.42) | GCKMEN1KMT2ADRD2DRD4 | |
| SCHEMBL2039421 | 0.72 | GCK (0.39) | GCK | |
| SCHEMBL2036096 | 0.69 | GCK (0.41) | GCKDRD2DRD4DRD3 | |
| SCHEMBL1960100 | 0.67 | GCK (0.61) | GCKRIPK1ALDH1A1NPSR1GAA | |
| SCHEMBL1960098 | 0.67 | GCK (0.61) | GCKRIPK1ALDH1A1NPSR1GAA | |
| SCHEMBL18766960 | 0.67 | RIPK1 (0.71) | RIPK1 | |
| SCHEMBL2054220 | 0.66 | DRD2 (0.34) | GCKRIPK1DRD2DRD4DRD3 | |
| SCHEMBL26686598 | 0.66 | GCK (0.50) | GCKDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |