Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 7/20 | 0.35 |
| ▸ | GCK | P35557 | 4/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2044900 | 0.83 | GCK (0.37) | GCK | |
| SCHEMBL1963036 | 0.79 | GCK (0.56) | HDAC6MTORGCK | |
| SCHEMBL1960236 | 0.79 | GCK (0.56) | HDAC6MTORGCK | |
| SCHEMBL2015678 | 0.78 | GCK (0.35) | GCK | |
| SCHEMBL2176812 | 0.74 | NAMPT (0.42) | NAMPTGCK | |
| SCHEMBL1961094 | 0.73 | HDAC6 (0.41) | HDAC6NAMPTGCK | |
| SCHEMBL2180465 | 0.71 | GCK (0.38) | NAMPTGCKLRRK2 | |
| SCHEMBL1961944 | 0.71 | GCK (0.55) | HDAC6MTORGCK | |
| SCHEMBL2036096 | 0.70 | GCK (0.41) | GCK | |
| SCHEMBL2178622 | 0.70 | NAMPT (0.34) | NAMPTGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | claimed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | claimed |