Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19859136 | 0.84 | EPHX2 (0.52) | HPGDRAB9AHSD17B10PRMT5WDR77 | |
| SCHEMBL19864681 | 0.83 | RAB9A (0.48) | HPGDRAB9AHSD17B10PRMT5WDR77 | |
| SCHEMBL22145584 | 0.82 | RAB9A (1.00) | HPGDRAB9AHSD17B10NPC1KLF5 | |
| SCHEMBL14072996 | 0.80 | TSHR (0.61) | HPGDRAB9AHSD17B10PRMT5WDR77 | |
| SCHEMBL6981710 | 0.79 | KDM4E (0.60) | HPGDRAB9AHSD17B10NPC1ALDH1A1 | |
| SCHEMBL19260062 | 0.79 | RAB9A (0.52) | HPGDRAB9AHSD17B10NPC1ALDH1A1 | |
| SCHEMBL29566033 | 0.77 | MAPT (0.55) | RAB9AHSD17B10PRMT5WDR77NPC1 | |
| SCHEMBL4290086 | 0.77 | MAPT (0.55) | RAB9AHSD17B10PRMT5WDR77NPC1 | |
| SCHEMBL647939 | 0.77 | RAB9A (0.84) | HPGDRAB9AHSD17B10NPC1KLF5 | |
| SCHEMBL18280561 | 0.76 | ROCK2 (0.53) | PRMT5WDR77NPC1ALDH1A1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |