Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18375133 | 0.88 | CHRM1 (0.42) | HDAC2CHRNB2CHRNA4TSHRPOLB | |
| SCHEMBL19308678 | 0.86 | HDAC2 (0.44) | HDAC2RAB9AKCNK3KCNK9CHRNB2 | |
| SCHEMBL20368920 | 0.81 | HDAC2 (0.38) | HDAC2RAB9AKCNK3KCNK9CHRNB2 | |
| SCHEMBL18374888 | 0.80 | HDAC2 (0.40) | HDAC2KCNK3KCNK9CHRNB2CHRNA4 | |
| SCHEMBL18374920 | 0.80 | CHRNB2 (0.56) | HDAC2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL27373214 | 0.80 | CHRNB2 (0.56) | HDAC2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL1692767 | 0.80 | RAB9A (0.45) | HDAC2RAB9AKCNK3KCNK9CHRNB2 | |
| SCHEMBL16132847 | 0.80 | CHRNB2 (0.56) | HDAC2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14243062 | 0.80 | CHRNB2 (0.54) | HDAC2RAB9AKCNK3KCNK9CHRNB2 | |
| SCHEMBL13698848 | 0.79 | RAB9A (0.46) | HDAC2RAB9AKCNK3KCNK9CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10421756-B2 | Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase | RODIN THERAPEUTICS, INC. (US) | 2019-09-24 | — | — | US | disclosed |
| US-20180194760-A1 | HETEROBICYCLIC N-AMINOPHENYL-AMIDES AS INHIBITORS OF HISTONE DEACETYLASE | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2018-07-12 | — | — | US | disclosed |
| US-20180194760-A1 | HETEROBICYCLIC N-AMINOPHENYL-AMIDES AS INHIBITORS OF HISTONE DEACETYLASE | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2018-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194760-A1 | HETEROBICYCLIC N-AMINOPHENYL-AMIDES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC2, HDAC1, HDAC5 | HDAC2 1/4885RAB9A 2071/4885KCNK3 3346/4885 |
| US-10421756-B2 | Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase | HDAC2, HDAC1, HDAC5 | HDAC2 1/4885RAB9A 2071/4885KCNK3 3346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.