Sugi Predict

Sugi Predict / Compounds / SCHEMBL2036795

SCHEMBL2036795

SCHEMBL2036795

Nc1nccc(C2CC2)n1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ADORA2A P29274 3/20 0.45
▸ ADORA1 P30542 2/20 0.45
▸ HRH3 Q9Y5N1 5/20 0.44
▸ HSP90AA1 P07900 3/20 0.44
▸ AURKA O14965 1/20 0.44
▸ PRKACA P17612 1/20 0.44
▸ HRH4 Q9H3N8 3/20 0.39
▸ CDK1 P06493 2/20 0.39
▸ CDK2 P24941 2/20 0.39
▸ CAMKK2 Q96RR4 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ CDK5 Q00535 1/20 0.39
▸ CDK5R1 Q15078 1/20 0.39
▸ HSP90AB1 P08238 1/20 0.39
▸ PTK2 Q05397 1/20 0.39
▸ KMO O15229 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2018276 0.98 ADORA2A (0.44) ADORA2AADORA1HRH3HSP90AA1AURKA
SCHEMBL28317093 0.92 HRH4 (0.44) ADORA2AADORA1HRH3HSP90AA1AURKA
SCHEMBL1270087 0.92 HRH4 (0.49) ADORA2AADORA1HRH3HSP90AA1AURKA
SCHEMBL1334584 0.91 ADORA2A (0.40) ADORA2AADORA1HRH3HSP90AA1AURKA
SCHEMBL1334581 0.91 ADORA2A (0.40) ADORA2AADORA1HRH3HSP90AA1AURKA
SCHEMBL31226997 0.91 CDK1 (0.47) ADORA2AADORA1HRH3HSP90AA1AURKA
SCHEMBL1334272 0.90 HRH4 (0.47) ADORA2AADORA1HRH3HSP90AA1AURKA
SCHEMBL2571086 0.87 PIK3CD (0.50) ADORA2AADORA1HRH3HSP90AA1AURKA
SCHEMBL20292302 0.87 HRH4 (0.57) ADORA2AHRH3HSP90AA1AURKAPRKACA
SCHEMBL31227542 0.85 MAPK14 (0.44) ADORA2AADORA1HRH3HSP90AA1AURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108299400-A Substituted pyridine as PDE4 inhibitor and substituted pyrazine compound 达特神经科学(开曼)有限公司 2018-07-20 — — CN claimed
CN-105143207-B Substituted pyridine and substituted pyrazine compounds as PDE4 inhibitors 达特神经科学(开曼)有限公司 2018-04-24 — — CN claimed
CN-104470934-B Kinases inhibitor 爱仕达生物技术有限责任公司 2017-08-04 — — CN claimed
EP-0108708-B1 N-(CYCLOPROPYL-TRIAZINYL- AND -PYRIMIDINYL)-N'-(ARYLSULFONYL) UREAS WITH HERBICIDAL ACTIVITY CIBA-GEIGY AG (CH) 1989-06-14 — — EP claimed
EP-0108708-A2 N-(cyclopropyl-triazinyl- and -pyrimidinyl)-N'-(arylsulfonyl) ureas with herbicidal activity CIBA-GEIGY AG (CH) 1984-05-16 — — EP claimed
EP-4076459-B1 PRMT5 INHIBITORS MERCK SHARP & DOHME LLC (US) 2026-04-29 — — EP disclosed
US-12595248-B2 PRMT5 inhibitors MERCK SHARP & DOHME LLC (US) 2026-04-07 — — US disclosed
EP-4076460-B1 1,4-DIHYDRO-2H-SPIRO[ISOQUINOLINE-3,4'-PIPERIDINE DERIVATIVES AS PRMT5 INHIBITORS FOR THE TREATMENT OF CANCER MERCK SHARP & DOHME LLC (US) 2026-01-21 — — EP disclosed
US-12441730-B2 PRMT5 inhibitors MERCK SHARP & DOHME LLC (US) 2025-10-14 — — US disclosed
EP-4558498-A1 NOVEL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE SULFONAMIDE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2025-05-28 — — EP disclosed
US-20250122172-A1 SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS DART NEUROSCIENCE LLC 2025-04-17 — — US disclosed
CN-119546608-A Novel imidazopyridine and pyrazolopyridine sulfonamide derivatives 豪夫迈·罗氏有限公司 2025-02-28 — — CN disclosed
WO-2011075515-A1 AMINOPYRIMIDINES AS SYK INHIBITORS MERCK SHARP & DOHME CORP. (US) 2011-06-23 — — WO disclosed
US-20100035863-A1 2 Amino-Pyrimidine Derivatives As H4 Receptor Antagonists, Processes For Preparing Them And Their Use In Pharmaceutical Compositions UCB PHARMA, S.A. (BE) 2010-02-11 — — US disclosed
EP-1401836-A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES FOR THE PROPHYLAXIS AND TREATMENT OF HERPES VIRAL INFECTIONS SmithKline Beecham Corporation (US) 2004-03-31 — — EP disclosed
WO-2003000689-A1 IMIDAZO`1,2-A!PYRIDINE DERIVATIVES FOR THE PROPHYLAXIS AND TREATMENT OF HERPES VIRAL INFECTIONS SMITHKLINE BEECHAM CORPORATION (US) 2003-01-03 — — WO disclosed
EP-0108708-B1 N-(CYCLOPROPYL-TRIAZINYL- AND -PYRIMIDINYL)-N'-(ARYLSULFONYL) UREAS WITH HERBICIDAL ACTIVITY CIBA-GEIGY AG (CH) 1989-06-14 — — EP disclosed
US-4600428-A N-(cyclopropyl-pyrimidinyl-N'-(aryl-sulfonyl) ureas having herbicidal activity CIBA-GEIGY CORPORATION (US) 1986-07-15 — — US disclosed
US-4515626-A PLANT GROWTH REGULATORS CIBA GEIGY CORPORATION (US) 1985-05-07 — — US disclosed
EP-0108708-A2 N-(cyclopropyl-triazinyl- and -pyrimidinyl)-N'-(arylsulfonyl) ureas with herbicidal activity CIBA-GEIGY AG (CH) 1984-05-16 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250122172-A1 SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS PDE4A, PDE4B, PDE4D ADORA2A 254/4885ADORA1 413/4885HRH3 965/4885
US-12595248-B2 PRMT5 inhibitors PRMT5, PRMT1, PRMT6 ADORA2A 4041/4885ADORA1 2729/4885HRH3 355/4885
US-20100035863-A1 2 Amino-Pyrimidine Derivatives As H4 Receptor Antagonists, Processes For Preparing Them And Their Use In Pharmaceutical Compositions HRH4, HRH2, HRH3 ADORA2A 4/4885ADORA1 7/4885HRH3 3/4885
US-12441730-B2 PRMT5 inhibitors PRMT5, PRMT1, PRMT3 ADORA2A 4107/4885ADORA1 3004/4885HRH3 223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.