Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 19/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 2/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16896769 | 0.85 | BRD4 (0.46) | BRD4NR3C1BRD2BRD3CYP3A4 | |
| SCHEMBL21910523 | 0.79 | BRD4 (0.55) | BRD4NR3C1BRD2BRD3CYP3A4 | |
| SCHEMBL18321132 | 0.75 | BRD4 (0.51) | BRD4NR3C1BRD2BRD3CYP3A4 | |
| SCHEMBL20568814 | 0.73 | BRD4 (0.37) | BRD4NR3C1BRD2BRD3CYP3A4 | |
| SCHEMBL16896930 | 0.72 | NR3C1 (0.57) | BRD4NR3C1BRD2BRD3 | |
| SCHEMBL16906054 | 0.71 | BRD4 (0.41) | BRD4NR3C1CYP3A4CYP2C9 | |
| SCHEMBL16896894 | 0.69 | GPR119 (0.42) | BRD4 | |
| SCHEMBL16896893 | 0.66 | BRD4 (0.44) | BRD4NR3C1BRD2BRD3CYP3A4 | |
| SCHEMBL16896929 | 0.65 | NR3C1 (0.49) | BRD4NR3C1BRD2BRD3 | |
| SCHEMBL16896884 | 0.65 | BRD4 (0.41) | BRD4NR3C1BRD2BRD3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |