Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | NMT1 | P30419 | 3/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 2/20 | 0.32 |
| ▸ | CPT1A | P50416 | 1/20 | 0.32 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373750 | 0.87 | HDAC1 (0.36) | SCN9ABRD4HDAC1HDAC8HDAC6 | |
| SCHEMBL18326361 | 0.86 | SCN9A (0.39) | SCN9ABRD4NMT1PIK3CGPRMT5 | |
| SCHEMBL16896879 | 0.84 | BRD4 (0.39) | BRD4NMT1 | |
| SCHEMBL20373353 | 0.74 | HDAC1 (0.40) | SCN9ABRD4HDAC1HDAC8HDAC6 | |
| SCHEMBL16905954 | 0.74 | HDAC1 (0.40) | SCN9ABRD4NMT1HDAC1HDAC8 | |
| SCHEMBL20373769 | 0.73 | FGFR1 (0.36) | BRD4 | |
| SCHEMBL16905987 | 0.73 | L3MBTL1 (0.46) | SCN9ABRD4HDAC1HDAC8HDAC6 | |
| SCHEMBL18326359 | 0.72 | CPT1A (0.41) | BRD4HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL18326360 | 0.72 | HDAC6 (0.42) | SCN9ABRD4HDAC1HDAC8HDAC6 | |
| SCHEMBL18317132 | 0.71 | BRD4 (0.41) | BRD4L3MBTL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |