Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CCR9 | P51686 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 2/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373752 | 0.84 | PDE5A (0.40) | KMT2APDE5AMEN1ALDH1A1MAPT | |
| SCHEMBL16896798 | 0.83 | KMT2A (0.47) | KMT2APDE5ADCTPP1P2RX3MEN1 | |
| SCHEMBL18326397 | 0.81 | BRD4 (0.48) | KMT2APDE5APDE1B | |
| SCHEMBL5888197 | 0.70 | PDE1A (0.47) | KMT2APDE5AP2RX3MEN1ALDH1A1 | |
| SCHEMBL18326383 | 0.69 | PDE5A (0.46) | KMT2APDE5AP2RX3MEN1ALDH1A1 | |
| SCHEMBL16896919 | 0.69 | BRD4 (0.47) | PDE5APDE1BKDM4E | |
| SCHEMBL20357585 | 0.66 | BRD4 (0.47) | KMT2AP2RX3MEN1ALDH1A1MAPT | |
| SCHEMBL16896755 | 0.66 | ACHE (0.42) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL16905989 | 0.66 | HTR2A (0.45) | KMT2APDE5AMEN1ALDH1A1 | |
| SCHEMBL18326392 | 0.65 | BRD4 (0.49) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |