Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373785 | 0.84 | KMT2A (0.43) | PDE5AKMT2AMAPTL3MBTL1MEN1 | |
| SCHEMBL16905989 | 0.83 | HTR2A (0.45) | PDE5AGABRA1GABRA5KMT2APDE4B | |
| SCHEMBL18326392 | 0.80 | BRD4 (0.49) | TDP1ALDH1A1 | |
| SCHEMBL7987250 | 0.68 | SRC (0.63) | GABRA1GABRA5KMT2AP2RX7PDE4B | |
| SCHEMBL16896904 | 0.67 | GRIN1 (0.39) | GABRA1GABRA5GRIN1GRIN2BNOX4 | |
| SCHEMBL16896755 | 0.66 | ACHE (0.42) | KMT2APDE4BMAPTL3MBTL1MEN1 | |
| SCHEMBL16896782 | 0.66 | PDE1A (0.41) | PDE5AGRIN1GRIN2B | |
| SCHEMBL18326384 | 0.65 | BRD4 (0.49) | — | |
| SCHEMBL16896798 | 0.65 | KMT2A (0.47) | PDE5AKMT2AMAPTMEN1GRIN1 | |
| SCHEMBL20357625 | 0.65 | BRD4 (0.47) | GABRA1GABRA5PDE4BMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |