Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14705606 | 0.87 | PTGS2 (0.54) | PTGS2PTGS1KDM4ERAB9AALDH1A1 | |
| SCHEMBL13398662 | 0.86 | KDM4E (0.46) | PTGS2PTGS1KDM4EGAAALDH1A1 | |
| SCHEMBL268643 | 0.80 | KDM4E (0.49) | KDM4ERAB9AGAAALDH1A1ALOX5 | |
| SCHEMBL2547639 | 0.78 | KDM4E (0.47) | KDM4ERAB9AGAAALDH1A1ALOX5 | |
| SCHEMBL923230 | 0.77 | KDM4E (0.58) | KDM4ERAB9AGAAALDH1A1ALOX5 | |
| SCHEMBL269217 | 0.77 | HCRTR1 (0.46) | KDM4EGAAALDH1A1MAPTPIN1 | |
| SCHEMBL20376593 | 0.75 | KDM4E (0.44) | KDM4ERAB9AGAAALDH1A1ALOX5 | |
| SCHEMBL27834590 | 0.75 | KDM4E (0.44) | KDM4ERAB9AGAAALDH1A1ALOX5 | |
| SCHEMBL27786030 | 0.75 | KDM4E (0.44) | KDM4ERAB9AGAAALDH1A1ALOX5 | |
| SCHEMBL2185640 | 0.74 | HIPK4 (0.48) | PTGS2PTGS1KDM4ERAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2739143-B1 | PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5- MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS | FLYNN GARY A (US) | 2018-07-11 | — | — | EP | disclosed |