SCHEMBL20377232

SCHEMBL20377232

O=P(O)(O)C(Nc1cc(OCc2ccccc2)ccn1)P(=O)(O)O

nearest known ligand 0.60

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FDPS P14324 15/20 0.60
SMPD1 P17405 1/20 0.44
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
CA9 Q16790 2/20 0.42
CA12 O43570 1/20 0.42
GPR132 Q9UNW8 1/20 0.42
MMP2 P08253 1/20 0.42
MMP8 P22894 1/20 0.42
MMP14 P50281 1/20 0.42
CA14 Q9ULX7 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22365610 0.84 FDPS (0.43) FDPSSMPD1MEN1KMT2AGPR132
SCHEMBL20377234 0.81 FDPS (0.48) FDPS
SCHEMBL7784532 0.81 FDPS (0.52) FDPSMEN1KMT2ACA9CA12
SCHEMBL26697665 0.77 MEN1 (0.59) SMPD1MEN1KMT2A
SCHEMBL20377242 0.76 FDPS (0.56) FDPSSMPD1
SCHEMBL20377216 0.76 FDPS (0.59) FDPSCA12MMP8
SCHEMBL25674573 0.76 FDPS (0.45) FDPS
SCHEMBL15163917 0.75 FDPS (1.00) FDPSCA9CA12MMP8MMP14
SCHEMBL25682049 0.75 MEN1 (0.44) SMPD1MEN1KMT2A
SCHEMBL31336089 0.75 MAOB (0.50) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250367283-A1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFICIENT VACCINE ADJUVANT TSINGHUA UNIVERSITY (CN) 2025-12-04 US disclosed
EP-3348269-B1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFECTIVE VACCINE ADJUVANT UNIV TSINGHUA (CN) 2023-11-15 EP disclosed
EP-3348269-B1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFECTIVE VACCINE ADJUVANT UNIV TSINGHUA (CN) 2023-11-15 EP disclosed
US-20220387584-A1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFICIENT VACCINE ADJUVANT TSINGHUA UNIVERSITY (CN) 2022-12-08 US disclosed
US-11382971-B2 Mevalonate pathway inhibitor as highly-efficient vaccine adjuvant TSINGHUA UNIVERSITY (CN) 2022-07-12 US disclosed
US-20210008084-A1 MEVALONATE PATHWAY INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF TSINGHUA UNIVERSITY (CN) 2021-01-14 US disclosed
EP-3698797-A1 MEVALONIC ACID PATHWAY INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF Tsinghua University (CN) 2020-08-26 EP disclosed
US-20190321465-A1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFICIENT VACCINE ADJUVANT TSINGHUA UNIVERSITY (CN) 2019-10-24 US disclosed
US-20190321465-A1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFICIENT VACCINE ADJUVANT TSINGHUA UNIVERSITY (CN) 2019-10-24 US disclosed
WO-2019076269-A1 MEVALONIC ACID PATHWAY INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF 清华大学 2019-04-25 WO disclosed
EP-3348269-A1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFECTIVE VACCINE ADJUVANT Tsinghua University (CN) 2018-07-18 EP disclosed
EP-3348269-A1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFECTIVE VACCINE ADJUVANT Tsinghua University (CN) 2018-07-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190321465-A1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFICIENT VACCINE ADJUVANT GGPS1, HMGCR, COASY FDPS 4/4885SMPD1 606/4885MEN1 3545/4885
US-20250367283-A1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFICIENT VACCINE ADJUVANT COASY, GGPS1, HMGCR FDPS 4/4885SMPD1 652/4885MEN1 3454/4885
US-11382971-B2 Mevalonate pathway inhibitor as highly-efficient vaccine adjuvant GGPS1, HMGCR, COASY FDPS 4/4885SMPD1 625/4885MEN1 3542/4885
US-20210008084-A1 MEVALONATE PATHWAY INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF PDCD1, CD274, PDCD5 FDPS 16/4885SMPD1 319/4885MEN1 755/4885
US-20220387584-A1 MEVALONATE PATHWAY INHIBITOR AS HIGHLY-EFFICIENT VACCINE ADJUVANT COASY, GGPS1, HMGCR FDPS 4/4885SMPD1 654/4885MEN1 3438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.