Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 17/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20377818 | 0.83 | IRAK4 (0.42) | IRAK4 | |
| SCHEMBL20769478 | 0.82 | IRAK4 (0.47) | IRAK4 | |
| SCHEMBL16899031 | 0.82 | TLR8 (0.36) | IRAK4TLR8 | |
| SCHEMBL20377768 | 0.81 | L3MBTL3 (0.34) | IRAK4KDM5A | |
| SCHEMBL26684343 | 0.80 | KDM4E (0.42) | IRAK4KDM5ATLR8 | |
| SCHEMBL29384539 | 0.80 | IRAK4 (0.39) | IRAK4 | |
| SCHEMBL26684084 | 0.75 | KDM5A (0.40) | IRAK4KDM5A | |
| SCHEMBL20135458 | 0.74 | KDM5A (0.53) | KDM5A | |
| SCHEMBL29384558 | 0.73 | L3MBTL3 (0.37) | IRAK4KDM5ATLR8 | |
| SCHEMBL29386238 | 0.73 | IRAK4 (0.43) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180201609-A1 | INDAZOLE AND AZAINDAZOLE COMPOUNDS AS IRAK-4 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180201609-A1 | INDAZOLE AND AZAINDAZOLE COMPOUNDS AS IRAK-4 INHIBITORS | IRAK4, IRAK3, IRAK2 | IRAK4 1/4885KDM5A 220/4885TLR8 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.