Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12631008 | 0.75 | GCK (0.44) | GCKRIPK1DAO | |
| SCHEMBL1959440 | 0.75 | GCK (0.44) | GCKRIPK1DAO | |
| SCHEMBL19121174 | 0.75 | GCK (0.43) | GCKRIPK1RETKDRDAO | |
| SCHEMBL1959062 | 0.72 | GCK (0.48) | GCK | |
| SCHEMBL1959220 | 0.72 | GCK (0.43) | GCKRIPK1 | |
| SCHEMBL1961634 | 0.70 | GCK (0.48) | GCKRIPK1 | |
| SCHEMBL1961251 | 0.70 | MAPT (0.43) | GCKRIPK1DAO | |
| SCHEMBL8135643 | 0.70 | RIPK1 (0.47) | GCKRIPK1RETKDRDAO | |
| SCHEMBL1959701 | 0.70 | GCK (0.43) | GCKRIPK1LMNA | |
| SCHEMBL2981817 | 0.70 | DAO (0.49) | GCKRIPK1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |