Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20385148 | 0.90 | HTT (0.44) | HTTNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL20385135 | 0.86 | NPC1 (0.44) | HTTNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL20385160 | 0.85 | HTT (0.41) | HTTNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL20385130 | 0.82 | KDM4E (0.40) | HTTNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL20385158 | 0.82 | HTT (0.39) | HTTNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL20385128 | 0.82 | HTT (0.41) | HTTNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL20385147 | 0.82 | HPGD (0.48) | HTTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL20385163 | 0.81 | KCNN4 (0.38) | HTTNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL20385150 | 0.80 | ALDH1A1 (0.38) | HTTNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL20385084 | 0.80 | KDM4E (0.40) | HTTNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867215-B1 | TETRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | SANIONA AS (DK) | 2018-07-18 | — | — | EP | disclosed |