Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20385152 | 0.86 | HTT (0.47) | HTTALDH1A1POLBSIGMAR1SMN1; SMN2 | |
| SCHEMBL20385135 | 0.82 | NPC1 (0.44) | HTTPOLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20385115 | 0.82 | HTT (0.43) | HTTALDH1A1POLBSIGMAR1SMN1; SMN2 | |
| SCHEMBL16919552 | 0.81 | HTT (0.47) | HTTALDH1A1POLBSMN1; SMN2NPC1 | |
| SCHEMBL20385161 | 0.81 | HTT (0.43) | HTTALDH1A1POLBSMN1; SMN2NPC1 | |
| SCHEMBL20385154 | 0.81 | HTT (0.43) | HTTALDH1A1POLBSMN1; SMN2NPC1 | |
| SCHEMBL20385126 | 0.81 | HTT (0.39) | HTTALDH1A1POLBSMN1; SMN2NPC1 | |
| SCHEMBL20385133 | 0.79 | HTT (0.41) | HTTALDH1A1POLBSMN1; SMN2NPC1 | |
| SCHEMBL20385156 | 0.79 | HTT (0.41) | HTTPOLBSIGMAR1SMN1; SMN2NPC1 | |
| SCHEMBL20385153 | 0.79 | HTT (0.44) | HTTALDH1A1POLBSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867215-B1 | TETRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | SANIONA AS (DK) | 2018-07-18 | — | — | EP | disclosed |