SCHEMBL20388644

SCHEMBL20388644

CC(C)(F)CNCCc1c[nH]c2ccccc12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MC5R P33032 2/20 0.68
MC3R P41968 2/20 0.68
MC1R Q01726 2/20 0.68
HTR2A P28223 2/20 0.67
ALDH1A1 P00352 3/20 0.61
KDM4E B2RXH2 1/20 0.61
HTR1A P08908 1/20 0.61
HTT P42858 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
G6PD P11413 1/20 0.59
GLA P06280 1/20 0.58
KMT2A Q03164 3/20 0.58
MEN1 O00255 1/20 0.58
LMNA P02545 1/20 0.58
CYP1A2 P05177 1/20 0.58
PKM P14618 1/20 0.58
TSHR P16473 1/20 0.58
CYP2C19 P33261 1/20 0.58
BLM P54132 1/20 0.58
BCHE P06276 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19803338 0.94 MC5R (0.68) MC5RMC3RMC1RHTR2AALDH1A1
SCHEMBL17117987 0.88 HTR2A (0.70) MC5RMC3RMC1RHTR2AALDH1A1
SCHEMBL1972443 0.88 MC5R (0.68) MC5RMC3RMC1RHTR2AALDH1A1
SCHEMBL17232881 0.83 MC5R (0.83) MC5RMC3RMC1RHTR2AALDH1A1
SCHEMBL798249 0.82 MC1R (1.00) MC5RMC3RMC1RHTR2AALDH1A1
SCHEMBL7970552 0.81 MC5R (0.81) MC5RMC3RMC1RHTR2AALDH1A1
SCHEMBL1972829 0.80 HTR2A (1.00) MC5RMC3RMC1RHTR2AALDH1A1
SCHEMBL11344810 0.80 MC5R (0.73) MC5RMC3RMC1RHTR2AALDH1A1
SCHEMBL10923944 0.80 HTR2A (0.70) MC5RMC3RMC1RHTR2AALDH1A1
SCHEMBL25029618 0.79 MC5R (0.71) MC5RMC3RMC1RHTR2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3760623-A1 TETRAHYDRO-PYRIDO[3,4-B]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF F. Hoffmann-La Roche AG (CH) 2021-01-06 EP disclosed
EP-3233852-B1 TETRAHYDRO-PYRIDO[3,4-B]INDOLES AS ESTROGEN RECEPTOR MODULATORS AND USES THEREOF HOFFMANN LA ROCHE (CH) 2020-07-15 EP disclosed
WO-2018130124-A1 TRICYCLIC COMPOUND AS SELECTIVE ESTROGEN RECEPTOR DOWN-REGULATOR AND USE THEREOF 南京圣和药业股份有限公司 2018-07-19 WO disclosed
WO-2018130123-A1 PENTACYCLIC COMPOUND AS SELECTIVE ESTROGEN RECEPTOR DOWN-REGULATOR AND USE THEREOF 南京圣和药业股份有限公司 2018-07-19 WO disclosed