Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 18/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20389118 | 0.89 | NAMPT (0.69) | NAMPTROCK2 | |
| SCHEMBL20389432 | 0.89 | NAMPT (0.69) | NAMPTROCK2 | |
| SCHEMBL23431947 | 0.87 | NAMPT (0.77) | NAMPTROCK2 | |
| SCHEMBL20388984 | 0.84 | ROCK2 (0.68) | NAMPTROCK2 | |
| SCHEMBL13373356 | 0.82 | ROCK2 (0.74) | NAMPTROCK2 | |
| SCHEMBL20389132 | 0.82 | NAMPT (1.00) | NAMPTROCK2 | |
| SCHEMBL3249722 | 0.81 | ROCK2 (1.00) | NAMPTROCK2 | |
| SCHEMBL20389057 | 0.81 | NAMPT (0.65) | NAMPT | |
| SCHEMBL20389005 | 0.81 | NAMPT (0.73) | NAMPTROCK2 | |
| SCHEMBL20389174 | 0.81 | NAMPT (0.70) | NAMPTROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018132372-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2018-07-19 | — | — | WO | disclosed |