Sugi Predict

Sugi Predict / Compounds / SCHEMBL20399208

SCHEMBL20399208

SCHEMBL20399208

CCSc1cccc(NC(=O)O)c1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 5/20 0.41
▸ KMT2A Q03164 5/20 0.41
▸ MAPK1 P28482 2/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ RXFP1 Q9HBX9 1/20 0.39
▸ HPGD P15428 3/20 0.39
▸ EPHX2 P34913 1/20 0.39
▸ HSD17B10 Q99714 2/20 0.37
▸ RAB9A P51151 2/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ CASP3 P42574 1/20 0.37
▸ SENP8 Q96LD8 1/20 0.37
▸ SENP7 Q9BQF6 1/20 0.37
▸ CETP P11597 1/20 0.37
▸ DDR1 Q08345 1/20 0.37
▸ MAPT P10636 2/20 0.37
▸ ALDH1A1 P00352 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30092445 0.80 RXFP1 (0.42) RXFP1HPGDCETPDDR1ALDH1A1
SCHEMBL2089517 0.72 KMT2A (0.52) MEN1KMT2AMAPK1SMN1; SMN2RAB9A
SCHEMBL20399181 0.72 MEN1 (0.41) MEN1KMT2ASMN1; SMN2HPGDEPHX2
SCHEMBL15163036 0.70 ALDH1A1 (0.46) MEN1KMT2AMAPK1SMN1; SMN2HPGD
SCHEMBL777305 0.70 CXCR2 (0.43) MEN1KMT2ASMN1; SMN2RAB9ANPC1
SCHEMBL29722901 0.70 CXCR2 (0.43) MEN1KMT2ASMN1; SMN2RAB9ANPC1
SCHEMBL28277559 0.70 MAPT (0.62) MEN1KMT2AMAPK1ALOX15SMN1; SMN2
SCHEMBL17398523 0.69 RIPK1 (0.49) MEN1KMT2AHPGDRAB9AMAPT
SCHEMBL3415512 0.69 KMT2A (0.49) MEN1KMT2AMAPK1SMN1; SMN2RAB9A
SCHEMBL20577985 0.69 MEN1 (0.49) MEN1KMT2AMAPK1SMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240208947-A1 JAK1 SELECTIVE INHIBITORS ASTRAZENECA AB (SE) 2024-06-27 — — US disclosed
US-11897869-B2 JAK1 selective inhibitors ASTAZENECA AB (SE) 2024-02-13 — — US disclosed
EP-4219470-A1 JAK1 SELECTIVE INHIBITORS Astrazeneca AB (SE) 2023-08-02 — — EP disclosed
US-20210188821-A1 JAK1 SELECTIVE INHIBITORS ASTRAZENECA PHARMACEUTICALS LP 2021-06-24 — — US disclosed
US-10961228-B2 JAK1 selective inhibitors ASTRAZENECA AB (SE) 2021-03-30 — — US disclosed
WO-2018134213-A1 JAK1 SELECTIVE INHIBITORS ASTRAZENECA AB (SE) 2018-07-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11897869-B2 JAK1 selective inhibitors JAK1, JAK2, JAK3 MEN1 2067/4885KMT2A 982/4885MAPK1 43/4885
US-20240208947-A1 JAK1 SELECTIVE INHIBITORS JAK1, JAK2, JAK3 MEN1 2067/4885KMT2A 982/4885MAPK1 43/4885
US-20210188821-A1 JAK1 SELECTIVE INHIBITORS JAK1, JAK2, JAK3 MEN1 2067/4885KMT2A 982/4885MAPK1 43/4885
US-10961228-B2 JAK1 selective inhibitors JAK1, JAK2, JAK3 MEN1 2067/4885KMT2A 982/4885MAPK1 43/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.