Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | PPP5C | P53041 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 3/20 | 0.36 |
| ▸ | EDNRB | P24530 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.35 |
| ▸ | GRM6 | O15303 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325402 | 0.78 | POLB (0.39) | POLBLMNAALDH1A1MAPT | |
| SCHEMBL7273731 | 0.78 | POLB (0.39) | POLBLMNAALDH1A1MAPT | |
| SCHEMBL1933031 | 0.78 | POLB (0.39) | POLBLMNAALDH1A1MAPT | |
| SCHEMBL7325409 | 0.78 | POLB (0.39) | POLBLMNAALDH1A1MAPT | |
| SCHEMBL7280473 | 0.78 | POLB (0.39) | POLBLMNAALDH1A1MAPT | |
| SCHEMBL4069733 | 0.76 | POLB (0.39) | POLBLMNAALDH1A1TDP1CTDSP1 | |
| SCHEMBL3464997 | 0.76 | POLB (0.39) | POLBLMNAALDH1A1TDP1CTDSP1 | |
| SCHEMBL16756317 | 0.76 | POLB (0.39) | POLBLMNAALDH1A1TDP1CTDSP1 | |
| SCHEMBL11268014 | 0.75 | ALDH1A1 (0.44) | POLBALDH1A1 | |
| SCHEMBL5138206 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |
| US-3948939-A | 9-Acyl-1,2,3,4-tetrahydrocarbazole-3 and 4-carboxylic acids | STERLING DRUG INC. (US) | 1976-04-06 | — | — | US | disclosed |