Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 17/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 17/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 11/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16636635 | 0.85 | L3MBTL1 (0.53) | PKMGRIN1GRIN2AGRIA2POLB | |
| SCHEMBL16637185 | 0.85 | PKM (0.39) | PKMGRIN1GRIN2AGRIA2HTT | |
| SCHEMBL16637002 | 0.82 | GRIN2A (0.38) | PKMGRIN1GRIN2AGRIA2 | |
| SCHEMBL16637218 | 0.80 | KDM4E (0.49) | PKMGRIN1GRIN2AGRIA2TDP1 | |
| SCHEMBL16636617 | 0.79 | PKM (0.37) | PKMGRIN1GRIN2AGRIA2POLB | |
| SCHEMBL17975725 | 0.79 | PKM (0.37) | PKMGRIN1GRIN2AGRIA2POLB | |
| SCHEMBL16637031 | 0.77 | GRIN2A (0.52) | PKMGRIN1GRIN2AGRIA2 | |
| SCHEMBL16637466 | 0.77 | GRIN2A (0.45) | PKMGRIN1GRIN2AGRIA2POLB | |
| SCHEMBL16637258 | 0.76 | GRIN2A (0.53) | PKMGRIN1GRIN2AGRIA2 | |
| SCHEMBL16636630 | 0.75 | GRIN2A (0.67) | GRIN1GRIN2AGRIA2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055315-B1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2018-07-25 | — | — | EP | disclosed |