Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 9/20 | 0.52 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20403948 | 0.90 | ACHE (0.46) | ENPP2ACHEMEN1KMT2AALDH1A1 | |
| SCHEMBL15564401 | 0.86 | ENPP2 (0.70) | ENPP2LPAR1S1PR5 | |
| SCHEMBL15564399 | 0.86 | ENPP2 (0.70) | ENPP2LPAR1S1PR5 | |
| SCHEMBL15599913 | 0.84 | ENPP2 (0.49) | ENPP2LPAR1ACHE | |
| SCHEMBL15564772 | 0.84 | ENPP2 (0.49) | ENPP2LPAR1ACHE | |
| SCHEMBL15565749 | 0.84 | ENPP2 (0.49) | ENPP2LPAR1S1PR5GAAMEN1 | |
| SCHEMBL16860089 | 0.84 | ENPP2 (0.49) | ENPP2LPAR1S1PR5GAAMEN1 | |
| SCHEMBL15565216 | 0.84 | ENPP2 (0.49) | ENPP2LPAR1S1PR5GAAMEN1 | |
| SCHEMBL15565364 | 0.83 | ENPP2 (0.48) | ENPP2LPAR1S1PR5GRM2 | |
| SCHEMBL15599971 | 0.83 | ENPP2 (0.48) | ENPP2LPAR1S1PR5GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2879673-B1 | 1,5,6-substituted naphthalene derivatives as sphingosine 1 phosphate (S1P) receptor and/or autotaxin (ATX) modulators for treating inflammatory and autoimmune disorders | BIOGEN MA INC (US) | 2018-07-25 | — | — | EP | disclosed |