Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.34 |
| ▸ | RXRA | P19793 | 4/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22838030 | 0.88 | HSD17B10 (0.34) | NR1H2RXRANR1H3KDM1AEPHX2 | |
| SCHEMBL15229449 | 0.84 | EPHX2 (0.35) | NR1H2RXRANR1H3KDM1AEPHX2 | |
| SCHEMBL20404152 | 0.83 | HSD17B10 (0.35) | NR1H2RXRANR1H3KDM1AEPHX2 | |
| SCHEMBL27181462 | 0.82 | — | — | |
| SCHEMBL24529328 | 0.82 | — | — | |
| SCHEMBL15054838 | 0.76 | EPHX2 (0.37) | KDM1AEPHX2HSD17B10USP2SMN1; SMN2 | |
| SCHEMBL16352853 | 0.76 | EPHX2 (0.35) | NR1H2RXRANR1H3KDM1AEPHX2 | |
| SCHEMBL26151530 | 0.75 | EPHX2 (0.36) | NR1H2RXRANR1H3KDM1AEPHX2 | |
| SCHEMBL10215488 | 0.74 | HSD17B10 (0.39) | KDM1AEPHX2HSD11B1HSD17B10USP2 | |
| SCHEMBL2126924 | 0.74 | HSD17B10 (0.45) | NR1H2RXRANR1H3KDM1AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |