Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13331058 | 0.85 | PDE10A (0.56) | PDE10ARAB9AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL2458300 | 0.82 | PDE10A (0.53) | PDE10ARAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL11814538 | 0.81 | TDP1 (0.57) | PDE10ARAB9AMAPTHPGDTDP1 | |
| SCHEMBL3699763 | 0.79 | RAB9A (0.70) | RAB9AMAPTHPGDTDP1KDM4E | |
| SCHEMBL11814208 | 0.79 | RAB9A (0.55) | PDE10ARAB9AMAPTHPGDNPC1 | |
| SCHEMBL20406235 | 0.79 | MAPT (0.47) | PDE10ARAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL20406610 | 0.79 | PDE10A (0.51) | PDE10ARAB9ATDP1MEN1KMT2A | |
| SCHEMBL20406612 | 0.79 | PDE10A (0.48) | PDE10ARAB9AMAPTHPGDNPC1 | |
| SCHEMBL7910614 | 0.79 | KMT2A (0.59) | PDE10AMAPTSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL31395507 | 0.79 | PDE10A (0.51) | PDE10ARAB9ATDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351533-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2018-07-25 | — | — | EP | disclosed |