Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4007180 | 0.80 | TRPA1 (0.57) | MAPTPDE10ACARM1PRMT6POLB | |
| SCHEMBL4006790 | 0.79 | HTR1A (0.56) | MAPTCARM1PRMT6POLBCYP2C9 | |
| SCHEMBL20406531 | 0.79 | PDE10A (0.58) | MAPTPDE10AMEN1KMT2ARAB9A | |
| SCHEMBL4009097 | 0.77 | TRPA1 (0.52) | MAPTPDE10ACARM1RAB9AL3MBTL1 | |
| SCHEMBL20406300 | 0.75 | MAOB (0.46) | PDE10ACARM1KMT2APRMT6RAB9A | |
| SCHEMBL20406236 | 0.75 | HTR1A (0.39) | MAPTCARM1PRMT6POLBCYP2C9 | |
| SCHEMBL22826881 | 0.72 | EPAS1 (0.52) | MAPTCYP2C19LMNAMAPK1HTT | |
| SCHEMBL29533055 | 0.72 | EPAS1 (0.52) | MAPTCYP2C19LMNAMAPK1HTT | |
| SCHEMBL4008185 | 0.72 | PDE10A (0.44) | MAPTPDE10ACARM1PRMT6POLB | |
| SCHEMBL4011485 | 0.70 | P2RY1 (0.49) | MAPTPDE10ACARM1PRMT6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351533-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2018-07-25 | — | — | EP | disclosed |