Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20406303 | 0.85 | MEN1 (0.46) | PDE10AMEN1KMT2ADRD1GCK | |
| SCHEMBL20406151 | 0.83 | PDE10A (0.45) | PDE10AMEN1KMT2A | |
| SCHEMBL20406196 | 0.80 | PDE10A (0.43) | PDE10AMEN1KMT2ADRD1GCK | |
| SCHEMBL20406219 | 0.78 | PDE10A (0.46) | PDE10AMAPTALDH1A1 | |
| SCHEMBL20406612 | 0.78 | PDE10A (0.48) | PDE10AMEN1KMT2ADRD1TDP1 | |
| SCHEMBL20406603 | 0.76 | PDE10A (0.46) | PDE10ADRD1TDP1RAB9AALDH1A1 | |
| SCHEMBL20394521 | 0.75 | PDE10A (0.52) | PDE10AMEN1KMT2AKDM4CMAPT | |
| SCHEMBL20406262 | 0.75 | PDE10A (0.42) | PDE10AMEN1KMT2ADRD1MAPT | |
| SCHEMBL7910614 | 0.75 | KMT2A (0.59) | PDE10AMEN1KMT2ADRD1GCK | |
| SCHEMBL20406238 | 0.75 | PDE10A (0.48) | PDE10AMEN1KMT2ADRD1GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351533-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2018-07-25 | — | — | EP | disclosed |