Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3387141 | 0.78 | KIT (0.56) | PIK3CDMAP4K4MKNK1MKNK2MAPT | |
| SCHEMBL29740321 | 0.77 | PIK3CD (0.73) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL1257460 | 0.77 | PIK3CD (0.73) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL30337416 | 0.75 | PIK3CD (0.70) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL28511565 | 0.74 | PIK3CD (0.44) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL30388104 | 0.74 | LRRK2 (0.55) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL30640940 | 0.74 | PIK3CD (0.44) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL30269910 | 0.74 | PIK3CD (0.51) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL22164604 | 0.74 | PIK3CD (0.51) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL12369737 | 0.74 | LRRK2 (0.55) | PIK3CDMAP4K4MKNK1MKNK2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136202-A2 | COMPOUNDS AND METHODS FOR CDK8 MODULATION AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2018-07-26 | — | — | WO | disclosed |