Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.64 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.61 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.61 |
| ▸ | LTA4H | P09960 | 1/20 | 0.57 |
| ▸ | NOS3 | P29474 | 1/20 | 0.55 |
| ▸ | NOS2 | P35228 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29740321 | 1.00 | PIK3CD (0.73) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL30337416 | 0.97 | PIK3CD (0.70) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL30502351 | 0.89 | PIK3CD (0.61) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL1256963 | 0.89 | PIK3CD (0.61) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL29568613 | 0.87 | MAP4K4 (0.64) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL68829 | 0.87 | MAP4K4 (0.64) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL312830 | 0.85 | LTA4H (0.79) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL1091572 | 0.85 | PIK3CD (0.57) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL16848140 | 0.85 | PIK3CD (0.57) | PIK3CDMAP4K4MKNK1MKNK2LTA4H | |
| SCHEMBL20704158 | 0.85 | MAP4K4 (0.62) | PIK3CDMAP4K4MKNK1MKNK2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118325083-A | Photosensitive polyamic acid ester resin, photosensitive polyamic acid ester resin glue solution, preparation method and application thereof | 深圳先进电子材料国际创新研究院 | 2024-07-12 | — | — | CN | disclosed |
| US-9981964-B2 | Maleimide derivatives as modulators of wnt pathway | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-05-29 | — | — | US | disclosed |
| EP-3083622-B1 | MALEIMIDE DERIVATIVES AS MODULATORS OF WNT PATHWAY | AGENCY SCIENCE TECH & RES (SG) | 2018-03-21 | — | — | EP | disclosed |
| US-20180028507-A1 | 3-CARBAMOYLPHENYL-4-CARBOXAMIDE AND ISOPHTALAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-02-01 | — | — | US | disclosed |
| EP-3259263-A1 | 3-CARBAMOYLPHENYL-4-CARBOXAMIDE AND ISOPHTALAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY | Bayer Pharma Aktiengesellschaft (DE) | 2017-12-27 | — | — | EP | disclosed |
| US-20160318926-A1 | MALEIMIDE DERIVATIVES AS MODULATORS OF WNT PATHWAY | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2016-11-03 | — | — | US | disclosed |
| WO-2016131794-A1 | 3-CARBAMOYLPHENYL-4-CARBOXAMIDE AND ISOPHTALAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-08-25 | — | — | WO | disclosed |
| WO-2015187094-A1 | PHTHALIMIDE DERIVATIVES AS MODULATORS OF WNT PATHWAY | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-12-10 | — | — | WO | disclosed |
| US-20130035326-A1 | BIARYL COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2013-02-07 | — | — | US | disclosed |
| EP-2467137-A1 | BIARYL COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011022473-A1 | BIARYL COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2011-02-24 | — | — | WO | disclosed |
| US-20090203705-A1 | Spiro Compounds As NPY Y5 Receptor Antagonists | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | US | disclosed |
| WO-2009095377-A1 | SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| EP-1737852-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | Icagen, Inc. (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005100349-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203705-A1 | Spiro Compounds As NPY Y5 Receptor Antagonists | NPY4R, NPY1R, NPY5R | PIK3CD 2997/4885MAP4K4 2887/4885MKNK1 4103/4885 |
| US-20160318926-A1 | MALEIMIDE DERIVATIVES AS MODULATORS OF WNT PATHWAY | WNT1, WNT3, CTNNB1 | PIK3CD 3743/4885MAP4K4 2696/4885MKNK1 867/4885 |
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | KCNJ2, KCNH2, KCNQ1 | PIK3CD 964/4885MAP4K4 518/4885MKNK1 679/4885 |
| US-20180028507-A1 | 3-CARBAMOYLPHENYL-4-CARBOXAMIDE AND ISOPHTALAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY | WNT1, WNT3A, WNT3 | PIK3CD 610/4885MAP4K4 645/4885MKNK1 611/4885 |
| US-20130035326-A1 | BIARYL COMPOUNDS AND METHODS OF USE THEREOF | FLT3, CSF3R, CSF1R | PIK3CD 400/4885MAP4K4 506/4885MKNK1 715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.