Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.71 |
| ▸ | RAB9A | P51151 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | MAPT | P10636 | 5/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | ACHE | P22303 | 2/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11338689 | 0.88 | ALDH1A1 (0.56) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13906032 | 0.85 | NPC1 (0.73) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10115511 | 0.83 | NPC1 (0.93) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11968692 | 0.81 | NPC1 (0.69) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13514083 | 0.81 | NPC1 (0.68) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL12419614 | 0.80 | ALDH1A1 (0.66) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13064231 | 0.80 | ALDH1A1 (0.66) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5334470 | 0.79 | ACHE (0.56) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13906063 | 0.76 | ALDH1A1 (0.61) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL27001794 | 0.75 | MAPK1 (0.71) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136202-A2 | COMPOUNDS AND METHODS FOR CDK8 MODULATION AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2018-07-26 | — | — | WO | disclosed |