Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 4/20 | 0.38 |
| ▸ | CPT2 | P23786 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30067 | 0.99 | PKM (0.47) | PKMADAM17MEN1KMT2AALDH1A1 | |
| SCHEMBL2050004 | 0.94 | PKM (0.50) | PKMADAM17MEN1KMT2AALDH1A1 | |
| SCHEMBL2038319 | 0.87 | PKM (0.49) | PKMADAM17MEN1KMT2AALDH1A1 | |
| SCHEMBL2042725 | 0.86 | PKM (0.50) | PKMADAM17MEN1KMT2AALDH1A1 | |
| SCHEMBL27924756 | 0.82 | PKM (0.52) | PKMADAM17MEN1KMT2AALDH1A1 | |
| SCHEMBL12791471 | 0.79 | PKM (0.45) | PKMADAM17MEN1KMT2AALDH1A1 | |
| SCHEMBL31597092 | 0.79 | PKM (0.53) | PKMADAM17MEN1KMT2AALDH1A1 | |
| SCHEMBL22824514 | 0.79 | ALDH1A1 (0.44) | PKMADAM17MEN1KMT2AALDH1A1 | |
| SCHEMBL20807473 | 0.79 | ALDH1A1 (0.44) | PKMADAM17MEN1KMT2AALDH1A1 | |
| SCHEMBL30764694 | 0.78 | MAPT (0.39) | PKMADAM17MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |