SCHEMBL20411331

SCHEMBL20411331

CC(C)(C)c1ccc2c(-c3ccccc3C(=O)O)c3ccc(=O)cc-3oc2c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 5/20 0.55
▸ L3MBTL1 Q9Y468 1/20 0.55
▸ POLB P06746 3/20 0.51
▸ MEN1 O00255 3/20 0.51
▸ KMT2A Q03164 3/20 0.51
▸ ATM Q13315 2/20 0.51
▸ PLEC Q15149 1/20 0.51
▸ ALPL P05186 1/20 0.48
▸ ALPI P09923 1/20 0.48
▸ ALPG P10696 1/20 0.48
▸ FTO Q9C0B1 2/20 0.47
▸ DNASE1L3 Q13609 1/20 0.46
▸ PRMT1 Q99873 1/20 0.46
▸ KDM4E B2RXH2 2/20 0.45
▸ ABCB1 P08183 1/20 0.45
▸ SOS1 Q07889 1/20 0.44
▸ CA9 Q16790 7/20 0.44
▸ CA1 P00915 6/20 0.44
▸ CA2 P00918 6/20 0.44
▸ CFTR P13569 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10026007 0.86 USP2 (0.72) USP2L3MBTL1POLBMEN1KMT2A
SCHEMBL10060277 0.85 POLB (0.59) USP2L3MBTL1POLBMEN1KMT2A
SCHEMBL19370241 0.85 USP2 (0.64) USP2L3MBTL1POLBMEN1KMT2A
SCHEMBL107875 0.84 USP2 (0.76) USP2L3MBTL1POLBMEN1KMT2A
SCHEMBL29591827 0.84 USP2 (0.76) USP2L3MBTL1POLBMEN1KMT2A
SCHEMBL29781098 0.84 USP2 (0.76) USP2L3MBTL1POLBMEN1KMT2A
SCHEMBL8947940 0.84 USP2 (0.58) USP2L3MBTL1POLBMEN1KMT2A
SCHEMBL3430200 0.83 USP2 (0.74) USP2L3MBTL1POLBMEN1KMT2A
SCHEMBL7591292 0.83 USP2 (0.74) USP2L3MBTL1POLBMEN1KMT2A
SCHEMBL8451224 0.83 USP2 (0.74) USP2L3MBTL1POLBMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180207284-A1 FLUORESCENT PRODRUGS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2018-07-26 — — US disclosed
US-20180207284-A1 FLUORESCENT PRODRUGS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2018-07-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180207284-A1 FLUORESCENT PRODRUGS FOLH1, ENTPD5, PHPT1 USP2 3545/4885L3MBTL1 1840/4885POLB 2950/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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