Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 3/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10495198 | 0.87 | ALDH1A1 (0.89) | ALDH1A1KMT2ALMNAMEN1SMN1; SMN2 | |
| SCHEMBL25442220 | 0.86 | ALDH1A1 (0.71) | ALDH1A1KMT2ALMNAMEN1SMN1; SMN2 | |
| SCHEMBL19390999 | 0.83 | CA12 (0.58) | ALDH1A1KMT2ALMNAMEN1SMN1; SMN2 | |
| SCHEMBL19413181 | 0.83 | ALDH1A1 (0.64) | ALDH1A1KMT2ALMNAMEN1NPSR1 | |
| SCHEMBL104400 | 0.81 | KMT2A (0.78) | ALDH1A1KMT2ALMNAMEN1SMN1; SMN2 | |
| SCHEMBL12089434 | 0.81 | ALDH1A1 (0.78) | ALDH1A1KMT2ALMNAMEN1SMN1; SMN2 | |
| SCHEMBL10169258 | 0.80 | ALDH1A1 (0.96) | ALDH1A1KMT2ALMNAMEN1SMN1; SMN2 | |
| SCHEMBL1104737 | 0.80 | ALDH1A1 (0.90) | ALDH1A1KMT2ALMNAMEN1SMN1; SMN2 | |
| SCHEMBL26078951 | 0.80 | ALDH1A1 (0.76) | ALDH1A1KMT2ALMNAMEN1SMN1; SMN2 | |
| SCHEMBL23709723 | 0.80 | ALDH1A1 (0.76) | ALDH1A1KMT2ALMNAMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180208591-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. | 2018-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180208591-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | CYP3A5, PAICS, CYP4B1 | ALDH1A1 594/4885KMT2A 1556/4885LMNA 2821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.