Sugi Predict

Sugi Predict / Compounds / SCHEMBL10169258

SCHEMBL10169258

SCHEMBL10169258

CC(C)c1ccc(C(=O)N2CCC2)cc1

nearest known ligand 0.96

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 7/20 0.96
▸ KMT2A Q03164 6/20 0.96
▸ MEN1 O00255 3/20 0.96
▸ SMN1; SMN2 Q16637 2/20 0.96
▸ LMNA P02545 1/20 0.96
▸ POLB P06746 3/20 0.63
▸ HPGD P15428 5/20 0.62
▸ HTT P42858 1/20 0.57
▸ CHRNA7 P36544 1/20 0.56
▸ L3MBTL1 Q9Y468 1/20 0.53
▸ HSD17B10 Q99714 1/20 0.53
▸ MAPT P10636 1/20 0.52
▸ MAPK1 P28482 1/20 0.51
▸ MGLL Q99685 1/20 0.50
▸ MLYCD O95822 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1104737 0.96 ALDH1A1 (0.90) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL10169253 0.95 ALDH1A1 (0.87) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL10495198 0.92 ALDH1A1 (0.89) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL17465250 0.91 KMT2A (0.85) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL12920008 0.86 ALDH1A1 (0.72) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL12089434 0.86 ALDH1A1 (0.78) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL19670980 0.86 ALDH1A1 (0.73) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL104400 0.86 KMT2A (0.78) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL23709723 0.84 ALDH1A1 (0.76) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL12015795 0.84 ALDH1A1 (0.71) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230043159-A1 MATRIPTASE 2 INHIBITORS AND USES THEREOF DISC MEDICINE, INC. 2023-02-09 — — US disclosed
US-10421743-B2 Tetrahydroisoquinolines as PRMT5 inhibitors CTXT PTY LTD (AU) 2019-09-24 — — US disclosed
US-20190071425-A1 TETRAHYDROISOQUINOLINES AS PRMT5 INHIBITORS CTXT PTY LTD (AU) 2019-03-07 — — US disclosed
US-10005792-B2 Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitors CTXT PTY. LTD. (AU) 2018-06-26 — — US disclosed
US-20170313713-A1 AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS CTXT PTY. LTD. (AU) 2017-11-02 — — US disclosed
US-20170298075-A1 TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS CTXT PTY. LTD. (AU) 2017-10-19 — — US disclosed
US-20170283407-A1 TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS CTXT PTY. LTD. (AU) 2017-10-05 — — US disclosed
US-9533986-B2 Bicyclic dihydropyridone kinase inhibitors PORTOLA PHARMACEUTICALS, INC. (US) 2017-01-03 — — US disclosed
US-9469654-B2 Bicyclic oxa-lactam kinase inhibitors PORTOLA PHARMACEUTICALS, INC. (US) 2016-10-18 — — US disclosed
US-20150252056-A1 BICYCLIC OXA-LACTAM KINASE INHIBITORS ALEXION PHARMACEUTICALS, INC. 2015-09-10 — — US disclosed
US-9040530-B2 1,2,4-triazine-6-carboxamide kinase inhibitors PORTOLA PHARMACEUTICALS, INC. (US) 2015-05-26 — — US disclosed
US-20140113931-A1 SUBSTITUTED PICOLINAMIDE KINASE INHIBITORS PORTOLA PHARMACEUTICALS, INC. (US) 2014-04-24 — — US disclosed
US-8586751-B2 Nicotinamide compounds useful as kinase modulators BRISTOL-MYERS SQUIBB COMPANY (US) 2013-11-19 — — US disclosed
US-20120082702-A1 NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS BRISTOL-MEYERS SQUIBB COMPANY 2012-04-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10005792-B2 Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitors PRMT5, PRMT1, PRMT3 ALDH1A1 2987/4885KMT2A 49/4885MEN1 612/4885
US-20170313713-A1 AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS PRMT5, PRMT1, PRMT3 ALDH1A1 2910/4885KMT2A 55/4885MEN1 586/4885
US-20170298075-A1 TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS PRMT5, PRMT1, PRMT3 ALDH1A1 4190/4885KMT2A 38/4885MEN1 324/4885
US-20150252056-A1 BICYCLIC OXA-LACTAM KINASE INHIBITORS SYK, BTK, JAK2 ALDH1A1 4320/4885KMT2A 1316/4885MEN1 4381/4885
US-20140113931-A1 SUBSTITUTED PICOLINAMIDE KINASE INHIBITORS SYK, LCK, BTK ALDH1A1 4736/4885KMT2A 1096/4885MEN1 4593/4885
US-20190071425-A1 TETRAHYDROISOQUINOLINES AS PRMT5 INHIBITORS PRMT5, PRMT1, PRMT3 ALDH1A1 4294/4885KMT2A 46/4885MEN1 162/4885
US-20120082702-A1 NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS NADK, BTK, NAMPT ALDH1A1 2193/4885KMT2A 2299/4885MEN1 3526/4885
US-10421743-B2 Tetrahydroisoquinolines as PRMT5 inhibitors PRMT5, PRMT1, PRMT3 ALDH1A1 4294/4885KMT2A 46/4885MEN1 162/4885
US-20170283407-A1 TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS PRMT5, PRMT3, PRMT1 ALDH1A1 4354/4885KMT2A 34/4885MEN1 367/4885
US-20230043159-A1 MATRIPTASE 2 INHIBITORS AND USES THEREOF MMP7, MATR3, SPINT2 ALDH1A1 3877/4885KMT2A 1072/4885MEN1 772/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.