Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 7/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 7/20 | 0.48 |
| ▸ | CACNA1I | Q9P0X4 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20432638 | 0.90 | HDAC6 (0.58) | KMT2AMEN1POLBHDAC1HDAC6 | |
| SCHEMBL17078604 | 0.90 | HDAC6 (0.58) | KMT2AMEN1POLBHDAC1HDAC6 | |
| SCHEMBL17078692 | 0.90 | CA1 (0.47) | CACNA1GCACNA1HCACNA1IKDM4EKMT2A | |
| SCHEMBL20421186 | 0.88 | DPP4 (0.50) | CACNA1GCACNA1HCACNA1IPTGER4SMN1; SMN2 | |
| SCHEMBL17078470 | 0.84 | FAAH (0.50) | KDM4EHDAC1HDAC6 | |
| SCHEMBL20420975 | 0.82 | PLA2G1B (0.52) | KDM4EKMT2AMEN1NPSR1SMN1; SMN2 | |
| SCHEMBL20420995 | 0.81 | PLA2G1B (0.55) | KDM4EKMT2AMEN1POLBNPSR1 | |
| SCHEMBL20420932 | 0.81 | CACNA1G (0.56) | CACNA1GCACNA1HCACNA1I | |
| SCHEMBL20420931 | 0.81 | HDAC1 (0.60) | KDM4EKMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL20420981 | 0.81 | HDAC1 (0.60) | KDM4EKMT2AMEN1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116859-B1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2018-08-01 | — | — | EP | disclosed |