Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TPH1 | P17752 | 1/20 | 0.35 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | PRKDC | P78527 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20424764 | 1.00 | KMT2A (0.39) | KMT2AMAPTALDH1A1LMNACSF1R | |
| SCHEMBL23589253 | 0.89 | PRKDC (0.46) | KMT2AMAPTALDH1A1HSD17B10GAA | |
| Hydrochloric Acid SCHEMBL20424423 | 0.88 | PRKDC (0.45) | KMT2AMAPTALDH1A1HSD17B10GAA | |
| SCHEMBL32659964 | 0.87 | ALDH1A1 (0.36) | KMT2AMAPTALDH1A1HSD17B10GAA | |
| Hydrochloric Acid SCHEMBL20424810 | 0.86 | ALDH1A1 (0.36) | KMT2AMAPTALDH1A1HSD17B10GAA | |
| SCHEMBL17872095 | 0.85 | MAPT (0.36) | KMT2AMAPTALDH1A1LMNAGAA | |
| SCHEMBL23683804 | 0.83 | FFAR1 (0.35) | KMT2AMAPTALDH1A1GAAHTR3E | |
| SCHEMBL23683833 | 0.83 | PKM (0.35) | KMT2AMAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL23589298 | 0.83 | MAPT (0.35) | KMT2AMAPTALDH1A1LMNAGAA | |
| Hydrochloric Acid SCHEMBL20424703 | 0.82 | FFAR1 (0.35) | KMT2AMAPTALDH1A1GAAHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018138359-A1 | RORGAMMA MODULATORS AND USES THEREOF | GENFIT (FR) | 2018-08-02 | — | — | WO | disclosed |
| WO-2018138362-A1 | N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXA ZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES | GENFIT (FR) | 2018-08-02 | — | — | WO | disclosed |