Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 10/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.60 |
| ▸ | RAF1 | P04049 | 4/20 | 0.60 |
| ▸ | GCGR | P47871 | 6/20 | 0.58 |
| ▸ | MGAM | O43451 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SI | P14410 | 1/20 | 0.53 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23736210 | 0.98 | MAPK13 (0.58) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL11516210 | 0.89 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL30903772 | 0.88 | MAPK13 (0.65) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL23758282 | 0.86 | GAA (0.58) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL17810813 | 0.84 | MAPK13 (0.45) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL20425689 | 0.84 | GAA (0.58) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL13115539 | 0.83 | MAPK14 (0.60) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL7367947 | 0.83 | NPY5R (0.63) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL30903778 | 0.83 | PRMT5 (0.59) | — | |
| Hydrochloric Acid SCHEMBL23736197 | 0.83 | GAA (0.57) | MAPK13MAPK12MAPK11MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12403128-B2 | Compositions and methods for blocking sodium channels | Univerity of Virginia Patent Foundation (US) | 2025-09-02 | — | — | US | disclosed |
| EP-3573957-B1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | RIVARA MIRKO (IT) | 2023-04-26 | — | — | EP | disclosed |
| EP-3573957-B1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | RIVARA MIRKO (IT) | 2023-04-26 | — | — | EP | disclosed |
| US-20220047554-A1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | UNIVERSITY OF VIRGINIA | 2022-02-17 | — | — | US | disclosed |
| US-11090289-B2 | Compositions and methods for blocking sodium channels | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2021-08-17 | — | — | US | disclosed |
| US-11090289-B2 | Compositions and methods for blocking sodium channels | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2021-08-17 | — | — | US | disclosed |
| WO-2018140504-A1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | PATEL MANOJ K (US) | 2018-08-02 | — | — | WO | disclosed |
| WO-2018140504-A1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | PATEL MANOJ K (US) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12403128-B2 | Compositions and methods for blocking sodium channels | SCN3A, SCN1B, SCN2B | MAPK13 2204/4885MAPK12 2707/4885MAPK11 1785/4885 |
| US-11090289-B2 | Compositions and methods for blocking sodium channels | SCN3A, SCN1B, SCN2B | MAPK13 2204/4885MAPK12 2707/4885MAPK11 1785/4885 |
| US-20220047554-A1 | COMPOSITIONS AND METHODS FOR BLOCKING SODIUM CHANNELS | SCN3A, SCN1B, SCN2B | MAPK13 2204/4885MAPK12 2707/4885MAPK11 1785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.