SCHEMBL20427542

SCHEMBL20427542

N#Cc1ccc(-c2cc(-c3ccccc3)nc(N)n2)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 6/20 0.69
ADORA2A P29274 5/20 0.69
CYP1A1 P04798 1/20 0.60
CYP1B1 Q16678 1/20 0.60
HRH4 Q9H3N8 2/20 0.56
HRH3 Q9Y5N1 2/20 0.56
CA12 O43570 1/20 0.55
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55
CA7 P43166 1/20 0.55
CA9 Q16790 1/20 0.55
HTR1A P08908 1/20 0.55
ADRA2A P08913 1/20 0.55
ADRA2C P18825 1/20 0.55
HTR1D P28221 1/20 0.55
HTR2A P28223 1/20 0.55
HTR2C P28335 1/20 0.55
HTR7 P34969 1/20 0.55
KDM4E B2RXH2 3/20 0.54
HSP90AA1 P07900 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19417246 0.83 ADORA2A (0.91) ADORA1ADORA2ACYP1A1CYP1B1HRH4
SCHEMBL4904514 0.83 ADORA2A (1.00) ADORA1ADORA2ACYP1A1CYP1B1HRH4
SCHEMBL19862133 0.83 GABRA1 (0.54) ADORA1ADORA2AKDM4EGABRA1GABRG2
SCHEMBL15308225 0.83 L3MBTL1 (0.69) ADORA1ADORA2AKDM4EGABRA1GABRG2
SCHEMBL23383854 0.83 ABCG2 (0.64) ADORA1ADORA2AKDM4EGABRA1GABRG2
SCHEMBL23383851 0.83 ABCG2 (0.64) ADORA1ADORA2AKDM4EGABRA1GABRG2
SCHEMBL17051424 0.81 GABRA1 (0.56) ADORA1ADORA2AKDM4EGABRA1GABRG2
SCHEMBL19164377 0.81 GABRA1 (0.56) ADORA1ADORA2AKDM4EGABRA1GABRG2
SCHEMBL22814503 0.81 ABCG2 (0.62) ADORA1ADORA2AKDM4EGABRA1GABRG2
SCHEMBL19920851 0.81 MYC (0.59) ADORA1ADORA2AKDM4EGABRA1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE46974-E1 Organic electroluminescence device IDEMITSU KOSAN CO., LTD. (JP) 2018-07-31 US disclosed